Homer2 and Alcohol: A Mutual Interaction
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چکیده
منابع مشابه
Homer2 and Alcohol: A Mutual Interaction
The past two decades of data derived from addicted individuals and preclinical animal models of addiction implicate a role for the excitatory glutamatergic transmission within the mesolimbic structures in alcoholism. The cellular localization of the glutamatergic receptor subtypes, as well as their signaling efficiency and function, are highly dependent upon discrete functional constituents of ...
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Homer proteins are integral to the assembly of proteins regulating glutamate signaling and synaptic plasticity. Constitutive Homer2 gene deletion [knock-out (KO)] and rescue with adeno-associated viral (AAV) transfection of Homer2b was used to demonstrate the importance of Homer proteins in neuroplasticity produced by repeated ethanol (EtOH) administration. Homer2 KO mice avoided drinking high ...
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ژورنال
عنوان ژورنال: Frontiers in Psychiatry
سال: 2017
ISSN: 1664-0640
DOI: 10.3389/fpsyt.2017.00268